CAMBRIDGE, Mass., March 12, 2019 — An optical imaging system developed by MIT researchers could enable physicians to identify tiny tumors deep within the body, leading to earlier detection and treatment of cancer. The researchers call their system DOLPHIN, which stands for “Detection of Optically Luminescent Probes using Hyperspectral and diffuse Imaging in Near-infrared.” The team’s goal with DOLPHIN is to detect cancer earlier by finding tiny tumors in a noninvasive way.
DOLPHIN can be used to image very small groups of cells deep within tissue and without any kind of radioactive labeling. The system uses fluorescent probes that emit light at different NIR wavelengths, depending on the type of doping element that is used. Hyperspectral imaging is used to enable simultaneous imaging in multiple wavelengths of NIR light. Using algorithms they developed, the researchers can analyze the data from the hyperspectral scan to identify the location of fluorescent probes. By analyzing the light from the various wavelength bands within the entire NIR spectrum, the researchers can determine the depth at which a probe is located.
According to the researchers, to date, the maximum reported depth using second-window NIR (NIR-II: 1000 to 1700 nm) fluorophores is 3.2 cm through tissue. DOLPHIN was able to track a 0.1-mm fluorescent probe through the digestive tract of a living mouse and to detect a signal to a tissue depth of 8 cm. The researchers also demonstrated that they could inject fluorescent particles into the body of a mouse or a rat and then image through the entire animal, to a depth of about 4 cm, to determine where the particles ended up.
In ongoing work, they are using a related version of this imaging system to try to detect ovarian tumors at an early stage. “Ovarian cancer is a terrible disease, and it gets diagnosed so late because the symptoms are so nondescript,” said professor Angela Belcher. “We want a way to follow recurrence of the tumors, and eventually a way to find and follow early tumors when they first go down the path to cancer or metastasis. This is one of the first steps along the way in terms of developing this technology.”
The researchers have also begun working on adapting DOLPHIN to detect other types of cancers such as pancreatic cancer, brain cancer, and melanoma.
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Writing in Scientific American in 2007, Harry A. Atwater of the California Institute of Technology predicted that a technology he called “plasmonics” could eventually lead to an array of applications, from highly sensitive biological detectors to invisibility cloaks. A decade later various plasmonic technologies are already a commercial reality, and others are transitioning from the laboratory to the market.
These technologies all rely on controlling the interaction between an electromagnetic field and the free electrons in a metal (typically gold or silver) that account for the metal’s conductivity and optical properties. Free electrons on a metal’s surface oscillate collectively when hit by light, forming what is known as surface plasmon. When a piece of metal is large, the free electrons reflect the light that hits them, giving the material its shine. But when a metal measures just a few nanometers, its free electrons are confined in a very small space, limiting the frequency at which they can vibrate. The specific frequency of the oscillation depends on the size of the metal nanoparticle. In a phenomenon called resonance, the plasmon absorbs only the fraction of incoming light that oscillates at the same frequency as the plasmon itself does (reflecting the rest of the light). This surface plasmon resonance can be exploited to create nanoantennas, efficient solar cells and other useful devices.
One of the best studied applications of plasmonic materials is sensors for detecting chemical and biological agents. In one approach, researchers coat a plasmonic nanomaterial with a substance that binds to a molecule of interest—say, a bacterial toxin. In the absence of the toxin, light shining on the material is reemitted at a specific angle. But if the toxin is present, it will alter the frequency of the surface plasmon and, consequently, the angle of the reflected light. This effect can be measured with great accuracy, enabling even trace amounts of the toxin to be detected and measured. Several start-ups are developing products based on this and related approaches—among them an internal sensor for batteries that allows their activity to be monitored to assist in increasing power density and charge rate and a device that can distinguish viral from bacterial infections. Plasmonics is also working its way into magnetic memory storage on disks. For instance, heat-assisted magnetic recording devices increase memory storage by momentarily heating tiny spots on a disk during writing.
In the medical field, light-activated nanoparticles are being tested in clinical trials for their ability to treat cancer. Nanoparticles are infused into the blood, after which they concentrate inside a tumor. Then light of the same frequency as the surface plasmon is shone into the mass, causing the particles to heat by resonance. The heat selectively kills the cancer cells in the tumor without hurting surrounding healthy tissue.
For more information: https://www.scientificamerican.com/article/plasmonic-materials/
A microchannel incorporated photonic crystal fiber (PCF)-based surface plasmon resonance (SPR) sensor for detection of low refractive index (RI) at near-infrared wavelength is presented in this paper. To attain a simple
and practically feasible mechanism, plasmonic material gold (Au) and sensing medium are placed outside the fiber. A thin layer of TiO2 is employed as an adhesive layer to strongly attach the Au with the silica glass. In the sensing range of 1.22 to 1.37, maximum sensitivities of 51,000 nm/RIU (RI unit) and 1872 RIU−1 are obtained with resolutions of 1.96 × 10−6 and 9.09 × 10−6 RIUs using wavelength and amplitude interrogation
methods, respectively. To the best of the authors’ knowledge, the obtained maximum wavelength sensitivity and resolution are the highest among reported PCF-based SPR sensors to date. The sensor also exhibits a maximum figure of merit of 566. Therefore, the proposed sensor would be an excellent candidate for a wide range of RI detection with higher accuracy for applications such as pharmaceutical inspection and leakage monitoring, bio-sensing, and other low RI analytes.
The surrounding medium adjacent to the sensing layer plays an important role to determine the phase-matching condition at resonance frequency. Moreover, there are other physical phenomena as well that are responsible for altering the phasematching condition of the SPR, namely, interparticle coupling, change in particle size or shape, charging of particles, and change in electron dynamics. The influence of shape can be very complex and leads to shifting resonance frequency toward shorter or longer wavelengths.
Under phase-matching point, also known as resonance condition, a sharp peak loss can be seen at which effective RIs of the fundamental core-guided
mode and SPP mode are equal.
A highly sensitive PCF-SPR sensor for low RI detection has been proposed and numerically analyzed in this paper. Square lattice and two leaky channels toward the Au-TiO2 coated microchannel have been designed to enhance the resonance effects significantly. As a result, in the sensing range of 1.22–1.37, the proposed sensor exhibits maximum wavelength and amplitude sensitivities of 51000 nm/RIU and 1872 RIU−1 with corresponding resolutions of 1.96 × 10−6 and 9.09 × 10−6 RIU, respectively.
A high FOM of 566 is also exhibited by the sensor. Moreover, incorporation of a microchannel reduces the amount of Au-TiO2 film as well as analyte in order to sense the changes in RI. The lower propagation loss of the proposed sensor is another attractive feature that makes the proposed sensor a well-suited candidate for an integrated SPR sensor, such as a
For more information: https://doi.org/10.1364/AO.58.001547
DURHAM, N.C., Feb. 19, 2019 — With small adjustments, a near-perfect absorber of electromagnetic waves can be changed into a coherent perfect absorber (CPA), a device that absorbs coherent light and shows near-zero reflectance and high absorption. A CPA, also known as a time-reversed laser, absorbs all of the energy from two identical electromagnetic waves in synchrony. The waves are absorbed as they enter the material from either side at precisely the same time.
This metamaterial features a zirconia ceramic built into a surface dimpled with cylinders, like the face of a Lego brick. After computationally modeling the metamaterial’s properties, the researchers found that they could create a basic CPA from the metamaterial by altering the cylinder size and spacing.
In contrast to existing CPAs, which work in one mode only, the CPA created by the Duke team has two overlapping modes, enabling it to absorb both aligned and misaligned waves. By changing the material’s parameters so that the two modes no longer overlapped, the researchers were able to create a CPA just like the CPAs currently described in the literature, but with more versatility. “Typical CPAs have only one variable, the material’s thickness,” said professor Kebin Fan. “We have three: the cylinders’ radius, height, and periodicity. This gives us a lot more room to tailor these modes and put them in the frequency spectrum where we want them, giving us a lot of flexibility for tailoring the CPAs.” By increasing the cylinder height in the metamaterial from 1.1 to 1.4 mm, the researchers gave the device the ability to switch between absorbing all phases of electromagnetic waves and absorbing only waves occurring in sync with each other. The team believes that it could be possible to engineer a material that can make this switch dynamically. “We haven’t done that yet. It is challenging, but it’s on our agenda,” said professor Willie Padilla. In principle, the researchers said, a device could be engineered that measures not just the intensity of incoming light like a normal camera, but also its phase. “If you’re trying to figure out the properties of a material, the more measurements you have, the more you can understand about the material,” Padilla said. “And while coherent detectors do exist … they’re extremely expensive to build through other technologies.”
The demonstrated system and theory could open the way to a new class of absorbers for future applications in hyperspectral imaging and energy harvesting.
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LAUSANNE, Switzerland, Feb. 13, 2019 — A way to produce glass metasurfaces that can be either rigid or flexible, developed by engineers from the EPFL Laboratory of Photonic Materials and Fiber Devices, could be used to fabricate all-dielectric optical metasurfaces quickly, at low temperatures, and with no need for a cleanroom. These metasurfaces could be used to build next-generation photonic circuits. Optical circuits, which are 10 to 100 times faster than electronic circuits and more energy-efficient, could transform the performance of many devices.
The EPFL engineers used dewetting to create dielectric glass metasurfaces, rather than metallic metasurfaces. First, they created a substrate textured with the desired architecture. Then, they deposited the material — chalcogenide glass — in thin films just tens of nanometers (nm) thick. The substrate was heated for a couple of minutes until the glass became fluid and nanoparticles began to form in the sizes and positions dictated by the substrate’s texture.
The engineers demonstrated the ability to tailor the position, shape, and size of nano-objects with feature sizes below 100 nm and with interparticle distances down to 10 nm. They used their method to generate optical nanostructures over rigid and soft substrates that were several centimeters in size, with optical performance and resolution comparable to traditional lithography-based processes. The metasurfaces are highly sensitive to changes in ambient conditions, thus able to detect the presence of very low concentrations of bioparticles, the team said.
Metasurfaces could enable engineers to make flexible photonic circuits and ultrathin optics for a host of applications, ranging from flexible tablet computers to solar panels with enhanced light-absorption characteristics. They could also be used to create flexible sensors to be placed directly on a patient’s skin, for example, to measure things such as pulse and blood pressure or to detect specific chemical compounds.
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Congratulations to our new paper ” Experimental study and micro-magnetic modeling of magnetization dynamics in L10-FePt thin film” by M. Shafei, M. M. Tehranchi, H. Falizkaran Yazdi, S. M. Hamidi, R. Yusupov, S. Nikitin
Among different magnetic thin films, L10 FePt due to high magnetocrystalline anisotropy is attracting much attention for applications in new generation of magnetic recording media. In this work, switching time and switching mechanism of magnetization as essential properties of L10 FePt film was studied by magneto-optical Kerr effect (MOKE) and time-resolved magneto-optical Kerr effect (TR-MOKE). For this purpose, static in plane and out of plane magnetic hysteresis loop of a L10 FePt film on (100) MgO was measured and modeled using polar and longitudinal MOKE and mumax code respectively. Furthermore, the switching time of magnetization was studied using laser induced ultrafast demagnetization and relaxation of the sample by TR-MOKE, in which for the first time, the magnetic field was applied in the plane of the sample for this measurement.
They consider the effect of electromagnetic coupling between localized surface plasmons in
a metallic nanoparticle (NP) and excitons or weakly interacting electron-hole pairs in a semiconductor
matrix where the NP is embedded.
An expression is derived for the NP polarizability renormalized by this coupling and two possible situations are analyzed, both compatible with the conditions for Fano-type resonances:
- a narrow-bound exciton transition overlapping with the NP surface plasmon resonance (SPR), and
- SPR overlapping with a parabolic absorption band due to electron-hole transitions in the semiconductor.
The absorption band line shape is strongly non-Lorentzian in both cases and similar to the typical Fano spectrum in the case (i).
However, it looks differently in the situation (ii) that takes place for gold NPs embedded in a CuO ﬁlm and the use of the renormalized polarizability derived in this work permits to obtain a very good ﬁt to the experimentally measured LSPR line shape.
Congratulations to our new paper ” Switching time Probing in electric field assisted magnetization of PbZrTiO3/Cobalt structure ” by M. Shafei, M. M. Tehranchi, S. M. Hamidi
Electric field assisted full magnetization switching in a multiferroic heterostructure composed of a PbZrTiO3 (PZT) substrate and 100nm Cobalt (Co) layer was investigated. For this, by measuring magnetic in plane anisotropy of the sample, using magneto-optical Kerr effect (MOKE), it was shown that the sample has a uniaxial anisotropy. In addition, the coercive field of the Co layer can be tuned by applying an electric field to the PZT which can be used in electric field assisted magnetization reversal in the Co layer. Direct measurement reveals that electric field assisted magnetization switching in layers take place in about 100 µs that is in compatibility with domain wall motion. Our measurement is a promising technique for probing of switching time in electric field assisted magnetization switching elements.
Congratulations to our new paper ” Tunable Piezophotonic effect in core shell nanoparticles prepared by laser ablation in liquids under external voltag”, by A.K. Kodeary, S. M. Hamidi.
We report an experimental study on the piezophotonic effect of gold and Lead Zirconate Titanate (PbZrTiO3) nanoparticles (NPs) and also core shell of them which prepared by laser ablation in liquid method. To reach these NPs and composite materials, the targets immersed in deionized water, and a polymeric solution of Poly vinyl pyrolidone (PVP) under Nd: YAG laser pulses irradiation. Linear and non-linear properties of these NPs were studied by optical spectroscopic and Z-scan technique. Furthermore, tunable nonlinear properties of them was measured under external electric field under light illumination to investigate the piezophotonic effect. Our results show that at the interface of PZT and Au, due to the schottky barrier, we have electron / hole recombination prevention which lead to the efficient enhancement in the nonlinear properties.
The silk fibers produced by Bombyx mori, the domestic silkworm, has been prized for millennia as a strong yet lightweight and luxurious material. Although synthetic polymers like nylon and polyester are less costly, they do not compare to silk’s natural qualities and mechanical properties. And according to research from the University of Pittsburgh’s Swanson School of Engineering, silk combined with carbon nanotubes may lead to a new generation of biomedical devices and so-called transient, biodegradable electronics.
“Silk is a very interesting material. It is made of natural fibers that humans have been using for thousands of years to make high quality textiles, but we as engineers have recently started to appreciate silk’s potential for many emerging applications such as flexible bioelectronics due to its unique biocompatibility, biodegradability and mechanical flexibility,” noted Mostafa Bedewy, assistant professor of industrial engineering at the Swanson School and lead author of the paper. “The issue is that if we want to use silk for such applications, we don’t want it to be in the form of fibers. Rather, we want to regenerate silk proteins, called fibroins, in the form of films that exhibit desired optical, mechanical and chemical properties.”
As explained by the authors in the video below, these regenerated silk fibroins (RSFs) however typically are chemically unstable in water and suffer from inferior mechanical properties, owing to the difficulty in precisely controlling the molecular structure of the fibroin proteins in RSF films. Bedewy and his NanoProduct Lab group, which also work extensively on carbon nanotubes (CNTs), thought that perhaps the molecular interactions between nanotubes and fibroins could enable “tuning” the structure of RSF proteins.
“One of the interesting aspects of CNTs is that, when they are dispersed in a polymer matrix and exposed to microwave radiation, they locally heat up,” Dr. Bedewy explained. “So we wondered whether we could leverage this unique phenomenon to create desired transformations in the fibroin structure around the CNTs in an “RSF-CNT” composite.”
According to Dr. Bedewy, the microwave irradiation, coupled with a solvent vapor treatment, provided a unique control mechanism for the protein structure and resulted in a flexible and transparent film comparable to synthetic polymers but one that could be both more sustainable and degradable. These RSF-CNT films have potential for use in flexible electronics, biomedical devices and transient electronics such as sensors that would be used for a desired period inside the body ranging from hours to weeks, and then naturally dissolve.
“We are excited about advancing this work further in the future, as we are looking forward to developing the science and technology aspects of these unique functional materials,” Dr. Bedewy said. ” From a scientific perspective, there is still a lot more to understand about the molecular interactions between the functionalization on nanotube surfaces and protein molecules. From an engineering perspective, we want to develop scalable manufacturing processes for taking cocoons of natural silk and transforming them into functional thin films for next generation wearable and implantable electronic devices.”
For more information: https://www.sciencedaily.com/releases/2018/10/181030121927.htm